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Dogs and Cats. DES is used primarily to treat urinary incontinence in spayed females. Estrogens increase urethral tone and help to prevent leaking or dribbling of urine. DES usually is effective。

DES has been used to treat estrogen responsive tumors, hyperplasia of the prostate gland and in perianal gland adenomas. However, neutering (castration) is the initial。

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